Acquisizione competenze di processo:Notably, all systems are excessively activated during inflammation, they have potent pro-inflammatory and prothrombotic effects and they increase vascular permeability, leading to edema. Although the dysregulation of each protein system is involved in the pathogenesis of common disorders, only a few rare diseases such as hereditary angioedema, paroxysmal nocturnal hemoglobinuria, atypical-uremic hemolytic syndrome, c3 glomerulopathies, rare coagulopathies, are approved for clinical treatment targeting renin-angiotensin, complement, coagulation and kks. the diagnosis and the treatment of these rare diseases are a challenge for health system because it is necessary to improve basic and clinical knowledge and management skills in order to offer the best response to patient’s needs.