Acquisizione competenze di processo:Sickle cell disease (scd) is one of the world’s most prevalent genetic diseases, and due to the impact on the geographical distribution of the hbs allele, scd has become a global public health issue. Children with scd frequently harbor steno-occlusive lesions in large cerebral arteries and microangiopathic lesions, causing ischemic stroke and silent infarcts that impact on neurocognitive development and quality of life.